Applications

Numerous publications have been made on AP/MALDI since its introduction in Analytical Chemistry by Laiko and co-workers in 2000. Compiled here is a list of AP-MALDI related publications, divided into two groups: peer-reviewed journal articles, and poster/conference presentations. Please feel free to e-mail us at msms@apmaldi.com if you think we have overlooked a publication(s).

Poster/Conference Presentations

High-Resolution Tissue Imaging Using Subatmospheric and Atmospheric MALDI sources, Eugene Moskovets1, Shelley N. Jackson2, Ludovic Muller2, Damon Barbacci2, Vladimir Doroshenko1, J. Albert Schultz2, Amina S. Woods2, 288910, Proceedings of the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 4-8, 2017. Affiliations: 1. MassTech Inc, Columbia, MD. 2. NIDA-IRP, NIH Baltimore, MD PDF

A High Resolution Atmospheric Pressure MALDI-Quadrupole-Orbitrap Platform Enables In Situ Analysis Of Biomolecules By Multi-Mode Ionization And Acquisition, Bingming Chen, Chuanzi OuYang, Zichuan Tian, Meng Xu, Lingjun Li, 287180, Proceedings of the 65th ASMS Conference on Mass Spectrometry and Allied Topics, Indianapolis, IN, June 4-8, 2017. Affiliations: University of Wisconsin-Madison, Madison, WI PDF

Characterization of chemical noise in AP MALDI using LTQ and Orbitrap mass spectrometer, Eugene Moskovets1, Vladimir M Doroshenko1, Shelley N Jackson2, Amina S Woods2, 279983, Proceedings of the 64th ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, 2016. Affiliations: 1. MassTech Inc, Columbia, MD. 2. NIDA-IRP, NIH Baltimore, MD PDF

A comparison of performance characteristics of atmospheric pressure and low-pressure matrix assisted laser desorption ionization sources, Vladimir M Doroshenko, Victor Laiko, Eugene Moskovets, 279985, Proceedings of the 64th ASMS Conference on Mass Spectrometry and Allied Topics, San Antonio, Texas, 2016. Affiliations: MassTech Inc, Columbia, MD PDF

A Field Deployable Ion Trap Mass Spectrometer with Atmospheric Pressure Interface, presented at the 9th Harsh-Environment Mass Spectrometry Workshop HEMS-2013 PDF

Performance characteristics of an AP MALDI ion source applied to second generation Exactive Mass Spectrometer, Maciej P Bromirski, Olaf Scheibner, Tabiwang N.Arrey, Kerstin Strupat, 249604, Proceedings of the 60th ASMS Conference on Mass Spectrometry and Allied Topics, Vancouver, Canada, 2012. Affiliations: Thermo Fisher Scientific GmbH, Bremen, Germany PDF

MT Explorer 50 Ion Trap Mass Spectrometer with AP MALDI Ion Source, MassTech Poster PDF

MT Explorer 50 Ion Trap Mass Spectrometer with DART Ion Source, MassTech PDF

Application Notes from MassTech

Comparison of AP-MALDI/MS with SubAP-MALDI (1 Torr) Mass Spectrometry, Application Note #1601, MassTech Inc, Columbia, MD PDF

Tissue Analysis and Imaging Using APMALDI(ng) UHR Ion Source with LTQ Orbitrap Velos, Ludovic Muller1, Shelley Jackson1, Aurelie Roux1, Amina S. Woods1, Berk Oktem, Application Note #1504. 1. National Institute on Drug Abuse, National Institutes of Health, 2. MassTech Inc, Columbia, MD PDF

Using APMALDI-HR Ion source on Thermo Orbitrap Fusion and TSQ Quantiva Mass Spectrometers for Peptide Analysis and Imaging, Berk Oktem, Application Note #1402, MassTech Inc, Columbia, MD, USA PDF

Using AP-MALDI on an AB Sciex Triple-TOF 5600 System, Berk Oktem, Application Note #1401, MassTech Inc, Columbia, MD PDF

Analysis of Microorganisms by Atmospheric Pressure Matrix Assisted Laser Desorption/Ionization and MT Explorer 100 Ion Trap Mass Spectrometer, Appavu Sundaram, Jane Razumovski, Berk Oktem, Jianhua Tang, Vladimir Doroshenko, Application Note #1201, MassTech Inc, Columbia, MD PDF

Agilent Specific AP/MALDI Publications

Versatile Protein Identification Using AP-MALDI Ion Trap Mass Spectrometry, Jose E. Meza, Donghui Yi, Christine A. Miller and Patrick D. Perkins, PharmaGenomics November/December 2003. Affiliations: Agilent Technologies PDF

Comparison of Sensitivity and Spectra between the AP-MALDI LC/MSD Trap SL System and Traditional Vacuum MALDI-TOF, Patrick Perkins, Jian Bai, Viorica Lopez-Avila,
and Christine Miller, Application Note, Agilent Technologies PDF

Agilent MALDI Protein Identification Solution, MS Application Guide, Agilent Technologies PDF

AP/MALDI on Agilent Mass Spectrometers, Presentation, 2009 PDF

Thermo Scientific Specific AP/MALDI Publications

Biological Applications of AP MALDI with Thermo Scientific Exactive Orbitrap MS, Kerstin Strupat, Olaf Scheibner, Tabiwang Arrey, Maciej Bromirski, Application Note #30224, Thermo Fisher Scientific, Bremen, Germany PDF

Sample Preparation Links

MALDI-TOF Sample Preparation Guide from MIT

Some recent AP/MALDI-related journal articles

Agrawal K and Wu HF (2008), “Bare silica nanoparticles as concentrating and affinity probes for rapid analysis of aminothiols, lysozyme and peptide mixtures using atmospheric-pressure matrix-assisted laser desorption/ionization ion trap and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry”, Rapid Commun. Mass Spectrom.. Vol. 22(3), pp. 283-290.

Agrawal K, Wu HF and Shrivas K (2008), “Reverse micellar microextraction for rapid analysis of thiol-containing peptides and amino acids by atmospheric-pressure matrix-assisted laser desorption/ionization ion trap and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry”, Rapid Commun. Mass Spectrom.., May, 2008. Vol. 22(9), pp. 1437-1444.

Berkout VD, Kryuchkov SI and Doroshenko VM (2007), “Modeling of ion processes in atmospheric pressure matrix-assisted laser desorption/ionisation”, Rapid Commun. Mass Spectrom.. Vol. 21(13), pp. 2046-2050.

Chong S-L, Nissilä T, Ketola RA, Koutaniemi S, Derba-Maceluch M, Mellerowicz EJ, Tenkanen M and Tuomainen P (2011), “Feasibility of using atmospheric pressure matrix-assisted laser desorption/ionization with ion trap mass spectrometry in the analysis of acetylated xylooligosaccharides derived from hardwoods and Arabidopsis thaliana “, Analytical and Bioanalytical Chemistry. Vol. 401(9), pp. 2995.

Creaser CS, Green PS, Kilby PM and Ratcliffe L (2006), “Capillary liquid chromatography/atmospheric-pressure matrix-assisted laser desorption/ionisation ion trap mass spectrometry: a comparison with liquid chromatography/matrix-assisted laser desorption/ionisation time-of-flight and liquid chromatography/electrospray ionisation quadrupole time-of-flight for the identification of tryptic peptides”, Rapid Commun. Mass Spectrom.. Vol. 20(5), pp. 829-836.

Daniel JM, Laiko VV, Doroshenko VM and Zenobi R (2005), “Interfacing liquid chromatography with atmospheric pressure MALDI-MS”, Anal Bioanal Chem., Nov, 2005. Vol. 383(6), pp. 895-902.

Grasso G, Fragai M, Rizzarelli E, Spoto G and Yeo KJ (2006), “In situ AP/MALDI-MS characterization of anchored matrix metalloproteinases”, J Mass Spectrom., Dec, 2006. Vol. 41(12), pp. 1561-1569.

Grasso G, Rizzarelli E and Spoto G (2007), “AP/MALDI-MS complete characterization of the proteolytic fragments produced by the interaction of insulin degrading enzyme with bovine insulin”, J Mass Spectrom., Dec, 2007. Vol. 42(12), pp. 1590-1598.

Gudlavalleti SK, Sundaram AK, Razumovski J and Doroshenko V (2008), “Application of atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry for rapid identification of Neisseria species”, J Biomol Tech., Jul, 2008. Vol. 19(3), pp. 200-204.

Hanton SD, Parees DM and Zweigenbaum J (2006), “The Fragmentation of Ethoxylated Surfactants by AP-MALDI-QIT “, Journal of the American Society for Mass Spectrometry . Vol. 17(3), pp. 453 – 458.

Hsieh S, Ku HY, Ke YT and Wu HF (2007), “Self-assembled-monolayer-modified silicon substrate to enhance the sensitivity of peptide detection for AP-MALDI mass spectrometry”, J Mass Spectrom., Dec, 2007. Vol. 42(12), pp. 1628-1636.

Ito E, Tominaga A, Waki H, Miseki K, Tomioka A, Nakajima K, Kakehi K, Suzuki M, Taniguchi N and Suzuki A (2012), “Structural Characterization of Monosialo-, Disialo- and Trisialo-gangliosides by Negative Ion AP-MALDI-QIT-TOF Mass Spectrometry with MSn Switching”, Neurochemical Research. Vol. 37(6), pp. 1315-1324.

Kassler A, Pittenauer E, Doerr N and Allmaier G (2009), “Electrospray ionization and atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry of antioxidants applied in lubricants”, Rapid Commun. Mass Spectrom.., Dec, 2009. Vol. 23(24), pp. 3917-3927.

Kellersberger KA, Yu ET, Merenbloom SI and Fabris D (2005), “Atmospheric pressure MALDI-FTMS of normal and chemically modified RNA\ “, Journal of the American Society for Mass Spectrometry . Vol. 16(2), pp. 199 – 207.

Konn DO, Murrell J, Despeyroux D and Gaskell SJ (2005), “Comparison of the effects of ionization mechanism, analyte concentration, and ion “cool-times” on the internal energies of peptide ions produced by electrospray and atmospheric pressure matrix-assisted laser desorption ionization”, J. Am. Soc. Mass Spectrom.., May, 2005. Vol. 16(5), pp. 743-751.

Levander F and James P (2005), “Automated protein identification by the combination of MALDI MS and MS/MS spectra from different instruments”, J. Proteome Res.. Vol. 4(1), pp. 71-74.

Li Y, Shrestha B and Vertes A (2008), “Atmospheric pressure infrared MALDI imaging mass spectrometry for plant metabolomics”, Anal. Chem.., Jan, 2008. Vol. 80(2), pp. 407-420.

Li Y, Shrestha B and Vertes A (2007), “Atmospheric pressure molecular imaging by infrared MALDI mass spectrometry”, Anal. Chem.., Jan, 2007. Vol. 79(2), pp. 523-532.

Mayrhofer C, Krieger S, Raptakis E and Allmaier G (2006), “Comparison of vacuum matrix-assisted laser desorption/ionization (MALDI) and atmospheric pressure MALDI (AP-MALDI) tandem mass spectrometry of 2-dimensional separated and trypsin-digested glomerular proteins for database search derived identification”, J. Proteome Res.., Aug, 2006. Vol. 5(8), pp. 1967-1978.

McEwen CN, Larsen BS and Trimpin S (2010), “Laserspray Ionization on a Commercial Atmospheric Pressure-MALDI Mass Spectrometer Ion Source: Selecting Singly or Multiply Charged Ions”, Analytical Chemistry. Vol. 82(12), pp. 4998-5001.

Navare A, Nouzova M, Noriega FG, Hernández-Martínez S, Menzel C and Fernández FM (2009), “On-chip solid-phase extraction pre-concentration/focusing substrates coupled to atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry for high sensitivity biomolecule analysis”, Rapid Communications in Mass Spectrometry. Vol. 23(4), pp. 477-486. John Wiley & Sons, Ltd..

Navare AT and Fernández FM (2010), “Inline pneumatically assisted atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry”, Journal of Mass Spectrometry. Vol. 45(6), pp. 635-642. Wiley Online Library.

Nguyen J and Russell SC (2010), “Targeted Proteomics Approach to Species-Level Identification of Bacillus thuringiensis Spores by AP-MALDI-MS “, Journal of the American Society for Mass Spectrometry . Vol. 21(6), pp. 993 – 1001.

Pihlainen K, Grigoras K, Franssila S, Ketola R, Kotiaho T and Kostiainen R (2005), “Analysis of amphetamines and fentanyls by atmospheric pressure desorption/ionization on silicon mass spectrometry and matrix-assisted laser desorption/ionization mass spectrometry and its application to forensic analysis of drug seizures”, J Mass Spectrom., Apr, 2005. Vol. 40(4), pp. 539-545.

Pittenauer E, Kassler A, Haubner R and Allmaier G (2011), “Different target surfaces for the analysis of peptides, peptide mixtures and peptide mass fingerprints by AP-MALDI ion trap-mass spectrometry”, Journal of Proteomics. Vol. 74(7), pp. 975-981.

Pittenauer E, Zehl M, Belgacem O, Raptakis E, Mistrik R and Allmaier G (2006), “Comparison of CID spectra of singly charged polypeptide antibiotic precursor ions obtained by positive-ion vacuum MALDI IT/RTOF and TOF/RTOF, AP-MALDI-IT and ESI-IT mass spectrometry”, J Mass Spectrom., Apr, 2006. Vol. 41(4), pp. 421-447.

Rapp E, Charvat A, Beinsen A, Plessmann U, Reichl U, Seidel-Morgenstern A, Urlaub H and Abel B (2009), “Atmospheric pressure free liquid infrared MALDI mass spectrometry: toward a combined ESI/ MALDI-liquid chromatography interface”, Anal. Chem.., Jan, 2009. Vol. 81(1), pp. 443-452.

Remes PM and Glish GL (2009), “On the time scale of internal energy relaxation of AP-MALDI and nano-ESI ions in a quadrupole ion trap”, J. Am. Soc. Mass Spectrom.., Oct, 2009. Vol. 20(10), pp. 1801-1812.

Sabu S, Yang FC, Wang YS, Chen WH, Chou MI, Chang HC and Han CC (2007), “Peptide analysis: solid phase extraction-elution on diamond combined with atmospheric pressure matrix-assisted laser desorption/ionization-Fourier transform ion cyclotron resonance mass spectrometry”, Anal. Biochem.., Aug, 2007. Vol. 367(2), pp. 190-200.

Salo PK, Salomies H, Harju K, Ketola RA, Kotiaho T, Yli-Kauhaluoma J and Kostiainen R (2005), “Analysis of Small Molecules by Ultra Thin-Layer Chromatography-Atmospheric Pressure Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry “, Journal of the American Society for Mass Spectrometry . Vol. 16(6), pp. 906 – 915.

Salo PK, Vilmunen S, Salomies H, Ketola RA and Kostiainen R (2007), “Two-dimensional ultra-thin-layer chromatography and atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry in bioanalysis”, Anal. Chem.., Mar, 2007. Vol. 79(5), pp. 2101-2108.

Schneider BB, Lock C and Covey TR (2005), “AP and vacuum MALDI on a QqLIT instrument”, J. Am. Soc. Mass Spectrom.., Feb, 2005. Vol. 16(2), pp. 176-182.

Schulz E, Karas M, Rosu F and Gabelica V (2006), “Influence of the matrix on analyte fragmentation in atmospheric pressure MALDI”, J. Am. Soc. Mass Spectrom.., Jul, 2006. Vol. 17(7), pp. 1005-1013.

Sekar R and Wu HF (2006), “Quantitative method for analysis of monensin in soil, water, and urine by direct combination of single-drop microextraction with atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry”, Anal. Chem.., Sep, 2006. Vol. 78(18), pp. 6306-6313.

Shrestha B, Nemes P, Nazarian J, Hathout Y, Hoffman EP and Vertes A (2010), “Direct analysis of lipids and small metabolites in mouse brain tissue by AP IR-MALDI and reactive LAESI mass spectrometry”, Analyst. Vol. 135, pp. 751-758. The Royal Society of Chemistry.

Shrivas K and Wu HF (2008), “Applications of silver nanoparticles capped with different functional groups as the matrix and affinity probes in surface-assisted laser desorption/ionization time-of-flight and atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry for rapid analysis of sulfur drugs and biothiols in human urine”, Rapid Commun. Mass Spectrom.., Sep, 2008. Vol. 22(18), pp. 2863-2872.

Shrivas K and Wu HF (2008), “Functionalized-multiwalled carbon nanotubes as a preconcentrating probe for rapid monitoring of cationic dyestuffs in environmental water using AP-MALDI/MS”, J Sep Sci., Oct, 2008. Vol. 31(20), pp. 3603-3611.

Shrivas K and Wu HF (2008), “Modified silver nanoparticle as a hydrophobic affinity probe for analysis of peptides and proteins in biological samples by using liquid-liquid microextraction coupled to AP-MALDI-ion trap and MALDI-TOF mass spectrometry”, Anal. Chem.., Apr, 2008. Vol. 80(7), pp. 2583-2589.

Shrivas K and Wu HF (2008), “Oxidized multiwalled carbon nanotubes for quantitative determination of cationic surfactants in water samples using atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry”, Anal. Chim. Acta., Nov, 2008. Vol. 628(2), pp. 198-203.

Shrivas K and Wu HF (2007), “A rapid, sensitive and effective quantitative method for simultaneous determination of cationic surfactant mixtures from river and municipal wastewater by direct combination of single-drop microextraction with AP-MALDI mass spectrometry”, J Mass Spectrom., Dec, 2007. Vol. 42(12), pp. 1637-1644.

Shrivas K and Wu HF (2007), “Quantitative bioanalysis of quinine by atmospheric pressure-matrix assisted laser desorption/ionization mass spectrometry combined with dynamic drop-to-drop solvent microextraction”, Anal. Chim. Acta., Dec, 2007. Vol. 605(2), pp. 153-158.

Shrivas K and Wu HF (2007), “Single drop microextraction as a concentrating probe for rapid screening of low molecular weight drugs from human urine in atmospheric-pressure matrix-assisted laser desorption/ionization mass spectrometry”, Rapid Commun. Mass Spectrom.. Vol. 21(18), pp. 3103-3108.

Shrivas K and Wu H-F (2008), “Applications of silver nanoparticles capped with different functional groups as the matrix and affinity probes in surface-assisted laser desorption/ionization time-of-flight and atmospheric pressure matrix-assisted laser desorption/ionization ion trap mass spectrometry for rapid analysis of sulfur drugs and biothiols in human urine”, Rapid Communications in Mass Spectrometry. Vol. 22(18), pp. 2863-2872. John Wiley & Sons, Ltd..

Sudhir PR, Shrivas K, Zhou ZC and Wu HF (2008), “Single drop microextraction using silver nanoparticles as electrostatic probes for peptide analysis in atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry and comparison with gold electrostatic probes and silver hydrophobic probes”, Rapid Commun. Mass Spectrom.., Oct, 2008. Vol. 22(19), pp. 3076-3086.

Sudhir PR, Wu HF and Zhou ZC (2005), “Identification of peptides using gold nanoparticle-assisted single-drop microextraction coupled with AP-MALDI mass spectrometry”, Anal. Chem.., Nov, 2005. Vol. 77(22), pp. 7380-7385.

Wang Y, Schneider BB, Covey TR and Pawliszyn J (2005), “High-performance SPME/AP MALDI system for high-throughput sampling and determination of peptides”, Anal. Chem.., Dec, 2005. Vol. 77(24), pp. 8095-8101.

Wu HF, Ku HY and Yen JH (2008), “Liquid-phase microextraction for rapid AP-MALDI and quantitation of nortriptyline in biological matrices”, J Sep Sci., Jul, 2008. Vol. 31(12), pp. 2288-2294.

Wu HF and Lin CH (2006), “Direct combination of immersed single-drop microextraction with atmospheric pressure matrix-assisted laser desorption/ionization tandem mass spectrometry for rapid analysis of a hydrophilic drug via hydrogen-bonding interaction and comparison with liquid-liquid extraction and liquid-phase microextraction using a dual gauge microsyringe with a hollow fiber”, Rapid Commun. Mass Spectrom.. Vol. 20(16), pp. 2511-2515.

Zhang J, Lamotte L, Dodds ED and Lebrilla CB (2005), “Atmospheric pressure MALDI Fourier transform mass spectrometry of labile oligosaccharides”, Anal. Chem.., Jul, 2005. Vol. 77(14), pp. 4429-4438.

Laiko VV, Baldwin MA and Burlingame AL (2000), “Atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry”, Anal. Chem.., Feb, 2000. Vol. 72(4), pp. 652-657.