MassTech’s APMALDI (ng) UHR source was featured in several presentations throughout ASMS 2017. We will be highlighting some of the key discussions in a series of reports from ASMS here on our website. For more details on the papers and for the original posters, you can always get copies from the ASMS website.
Bingming Chen, Chuanzi OuYang, Zichuan Tian, Meng Xu and Lingjun Li, University of Wisconsin-Madison School of Pharmacy, Department of Chemistry, Department of Biochemistry, “A High Resolution Atmospheric Pressure MALDI-Quadrupole-Orbitrap Platform Enables In Situ Analysis of Bio-Molecules by Multi-Mode Ionization and Acquisition”
Conclusions:
- AP/MALDI (ng) UHR source, developed by MassTech Inc., is a high resolution atmospheric pressure MALDI source, which is interchangeable with ESI source and has a laser dot of less than 10 um (microns).
- In this study, the source was coupled to QE HF to achieve high resolution analysis in both space and mass…
- Multiple ionization modes, including MALDI, LSI and MAI have been successfully performed in this platform without instrument modification…
- Full MS, targeted MS/MS, DDA and PRM acquisitions were achieved on standard neuropeptide mixtures and tissue sections…
- Overall, the AP/MALDI-Q-Orbitrap is a powerful instrument platform that is capable of multi-ionization and multi-acquisitions for various samples. It could be an attractive alternative to other high resolution MALDI instruments. (emphasis added)