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AP/MALDI (ng) HR Ion Source PDF Print E-mail
Monday, 01 June 2015 00:00

What is AP-MALDI?

The AP-MALDI (Atmospheric Pressure, Matrix Assisted Laser Desorption/Ionization) source has been our signature product since the inception of the company. Currently in its’ fifth generation -called AP-MALDI (ng) HR - our AP-MALDI ion source uses several key pieces of technology MassTech has developed over years of work with this product. Furthermore, as the AP-MALDI operates at atmospheric pressure (requiring zero pumping time after installation) samples are not required to be vacuum compatible. This gives you the ability to use volatile or semi-volatile solvents and matrices in your sample, allowing for new and non-traditional MALDI applications.

The AP-MALDI source is compatible with Mass Spectrometers from all major Mass Spectrometer manufacturers. Due to the atmospheric pressure interface, you can switch from ESI to AP-MALDI in minutes, if not seconds! For labs with occasional MALDI needs, or for labs without a dedicated MALDI Mass Spectrometer, the AP-MALDI source is the perfect solution.

At MassTech, we have developed applications using the AP-MALDI in conjunction with instruments with MS/MS capabilities, such as our own MT Explorer 50, allowing us to do MALDI MS/MS and do work such as detection and even identification of bacteria and other biological samples. If your instrument has accurate mass measurement capability, with the AP-MALDI you can do accurate mass MALDI. As a result, we have seen excellent results with instruments such as the Thermo QExactive Orbitrap and the latest Agilent 6000 series.

The AP-MALDI is sold world-wide through our network of distributors. Within the Continental United States, you can contact us directly for a price quote. For international deliveries, all quotes requests to This e-mail address is being protected from spambots. You need JavaScript enabled to view it will be redirected to the appropriate distributor. Agilent representatives can contact us directly for preferential pricing. There is a one-time installation/training fee for these units.

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Why select AP MALDI?
  • It is the most cost effective way to do MALDI MS/MS
  • It is sensitive - users can detect peptides at attmole level
  • Easily interchangeable with ESI in just minutes
  • “Softer” ionization (i.e., mostly +1 charge ions produced) due to fast thermalization of internal energies at atmospheric conditions
  • High throughput applications
  • Lower lifetime ownership cost